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Nature Reviews Neuroscience , 3 (6), 473-8

10.1016/j.reprotox.2009.06.013 118 SathyanarayanaS.SwanS

Matta K, Lefebvre T, Vigneau E, Cariou V, Marchand P, Guitton Y, et al

Para que uma substncia seja usada por via oral ou injetvel em humanos, so necessrios estudos que avaliem absoro, distribuio, metabolismo, excreo, toxicidade, dose, segurana em populaes especficas, interaes, eventos adversos e eficcia em desfechos clnicos