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In addition, it decreased pro-inflammatory cytokine levels of CXCL8, CXCL10, CCL5, and interleukin-6

People with very fair skin often carry MC1R gene variants (like R151C or R160W) that produce a receptor less responsive to melanocortin signaling

Gori AM, Giusti B, Piccardi B, Nencini P, Palumbo V, Nesi M, et al

The anti-inflammatory effects of decaf are comparable to those of regular coffee, which means decaf drinkers can enjoy these benefits without the effects of caffeine