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Finally, we examine the role of 5-HT 2A receptor-mediated neural inhibition in mediating the effects of these substances

doi:10.1016/j.jneumeth.2020.108827 93. Owen, J

This idea is supported by other neurodegenerative diseases experiencing severe localized copper deficiency, such as the motor neurons of ALS patients (Hilton et al., 2024), PD patients with up to 50% reduction of copper seen in the substantia nigra (Bisaglia and Bubacco, 2020), brain copper reductions in prion diseases (Sorenson, 2001), and notably Menkes disease which is characterized by an X-linked defect in copper transporting ATP7-A gene that leads to severe systemic copper deficiency and progressive neurodegeneration (Tmer and Mller, 2010)

The dose-response relationship of paracetamol and liver injury is in contrast to so-called idiosyncratic drug-induced liver injury, which is restricted to a subset of susceptible individuals