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Several studies have reported on the use of mesna concurrently with chemotherapy

[Google Scholar] 73.Zhou XY, Guo T, Lu YL, Hadiatullah H, Li P, Ding KL, et al

Epitope orientation sensitivity: if protective efficacy depends on conformationally constrained or spatially directional epitopes, orientation-defined systems (e.g., enzymatic ligation or SpyTag-mediated docking) are mandatory