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Research has found that, conversely, in a streptozotocin-induced type 1 diabetes rat model, reducing FPN levels leads to increased brain iron, causing ferroptosis, and ultimately resulting in cognitive impairment and decline (Hao et al., 2021)

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Peripheral nerve injury occurs along a spectrum from injuries in which some axonal continuity is maintained and injuries involving complete nerve transection 4,5,6

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The third major target is the selenoenzyme GPx4

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