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150 The main byproduct in mitochondria, ROS is also included

Activation of Nrf2-ARE may inhibit the production or expression of pro-inflammatory mediators to reduce early inflammation-mediated tissue damage (219)

Since OSA patients could benefit from the administration of non-benzodiazepine hypnotic [37], the administration of standardized Kava Kava might help alleviate OSA symptoms in the patients