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Improved insulin sensitivity lowers hyperinsulinemia-induced ovarian androgen production, which is a central driver of menstrual irregularity in many with PCOS

It was demonstrated that ferroptosis is highly correlated with cardiomyocyte death, and mammalian target of rapamycin (mTOR) plays an important role in protecting cardiomyocytes against excess iron and ferroptosis by inhibiting the production of lipid-derived ROS [105]

These include moving beyond single biomarkers to adopt multidimensional assessments that combine biomarkers, neuroimaging, digital phenotyping, and behavioral measures [580, 582, 610, 638]

This outcome may be attributed to the variable selection and the low frequency of highly informative variables in the stromal compartment expression datasets from both AMC cohorts