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Subsequent studies also confirmed that DMB can improve certain diseases by reducing TMAO concentrations, such as allogenic gain-versus-host disease (Wu et al., 2020) and endothelial dysfunction (Brunt et al., 2020)

Effects of probiotic supplementation on serum trimethylamine-N-oxide level and gut microbiota composition in young males: a double-blinded randomized controlled trial

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Research demonstrates that acetyl-L-carnitine ameliorates insulin resistance through multiple mechanisms: restoring tissue carnitine levels in skeletal muscle and myocardium, improving mitochondrial -oxidation of fatty acids to reduce accumulation of lipotoxic intermediates, enhancing glucose disposal and oxidation capacity, and reducing inflammatory signaling that impairs insulin receptor function