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The Permanente journal , 26(2), 8997

Recently, a structure-based screening has led to the discovery of the first NAPRT activators based on 1,2-dimethylbenzimidazole scaffolds 231 , but evidence for these compounds in boosting NAD + metabolism is still lacking

In light of recent discoveries regarding lactate-mediated Kla in tumor immunology and immunotherapy, this review provides a synthesis of the current understanding of the immunomodulatory effects of Kla and the translational landscape of Kla-targeted therapeutics