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In research protocols, epithalon is typically used at nanomolar concentrations in in vitro replicative senescence studies, and in chronic administration in mouse accelerated aging models (SAMP mice, Klotho knockouts)

In mice, SLC7A11/xCT is prominently expressed in the hippocampus, cortex, hypothalamus, and dentate gyrus (Sato et al., 2002)

Environmental factors, including light exposure, temperature, soil quality, and water availability, further modulate phytochemical profiles, with organic cultivation and stress conditions (e.g., drought or salinity) often enhancing secondary metabolite production

Optimizing mitochondria function in immune cells: implications for cancer immunotherapy