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Social, occupational, educational or other important functioning must also be negatively impaired by the change in mood." The site further goes on to explain that clinical depression is characterized by the presence of the majority of these symptoms: Depressed mood most of the day, nearly every day, as indicated by either subjective report (e.g., feeling sad or empty) or observation made by others (e.g., appears tearful)

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Sjgren T, Nord J, Ek M, Johansson P, Liu G, Geschwindner S (2013) Crystal structure of microsomal prostaglandin E2 synthase provides insight into diversity in the MAPEG superfamily