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Subsequent animal studies verify that exposure to nicotine or systemic administration of nicotine has consistent antinociceptive effects in different rodent models (for review, see Shi et al., 2010)

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As this occurs, we see the progressive integration of specific platforms: cardiovascular OoCs are serving as complementary tools, while blood-brain barrier-on-chip models are rapidly progressing to decrease dependence on animal models in neurological research