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Phase II and III clinical trials have reported side effects such as elevated estradiol levels (a form of estrogen), headaches, and abdominal discomfort, with no known long-term complications

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For further information on PRP you may download this PDF (Practical Pain Management article by David Krane, MD and Peter Everts, PhD) Prolotherapy Prolotherapy, also known as regenerative injection therapy, is an excellent treatment option for musculoskeletal (MSK) disorders and dysfunction of all types

It is critical to note that the safety profile for injectable or systemic use is far less established due to a lack of human research