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JAMA Cardiol 2018;3:252259

Nature 617 , 386394 (2023)

The generation of lipid peroxides is closely linked to intracellular iron levels, with excessive iron accumulation driving the production of ROS through the Fenton reaction, which, in turn, exacerbates lipid peroxidation ( Figure 1 )

A possible explanation might be that constitutive RAS pathway activity promotes TFRC (a gene related to iron metabolism) expression while suppressing the expression of iron storage proteins