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For instance, Niu et al

Nature 414, 105111

FIGURE 1 2.3.2 REV-ERB/ROR stabilizing loop The CLOCK-BMAL1 complex plays a crucial role in regulating its own expression by inhibiting the BMAL1 gene

Although the treatment of nervous system diseases targeting TIGAR has great application potential, it is unknown that whether promoting its overexpression would affect other tissues and organs or not, because TIGAR is expressed in many tissues and organs throughout the body