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Reactive oxygen species control protein degradation at the mitochondrial import gate

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A meta-analysis of studies on eight vitamins showed that persons with AD had significantly lower levels of vitamin C, E and A than those without cognitive impairment.[39] A cross-sectional study of older adults in Germany found significantly lower levels of vitamin C and -carotene in individuals with dementia than in the healthy individuals.[17] Another more recent meta-analysis of studies on vitamin levels in cerebrospinal fluid showed that persons with AD had significantly lower vitamin C, E, folate and B-12 levels.[47] Other findings in studies on rats show that vitamin C reduces generation of the -amyloid peptide and acetylcholinesterase activity

Relevantly, a negative expression correlation of PGC-1 and G6PC with miR-23a was also found in human specimens [53]