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[1] In the deamidation of an asparagine residue under physiological conditions, the side chain is attacked by the nitrogen atom of the following peptide group (in black at top right of Figure), forming an asymmetric succinimide intermediate (in red)

Moreover, as aforementioned, patients with active CD and those on a gluten free diet have significantly higher levels of proinflammatory cytokines in the plasma, such as INF-, interleukin (IL)-1, tumor necrosis factor- (TNF-), IL-6 and IL-8 compared to no celiac subjects [69]

Liver disease trends in the Asia-Pacific region for the next 50 years

10.1253/circj.69.1418 162 XieL.GuY.WenM.ZhaoS.WangW.MaY.et al (2016)