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II) Picroside-II is subjected to ester bond hydrolysis to form vanillic acid, which is further subjected to sulfate conjugation, glycine conjugation, glucuronidation, and demethylation

The CD44hyaluronic acid interaction is dominated by an extensive interaction network with the predominantly aliphatic residues that line the hook and a stretch of aromatic and basic amino acids located at the base of the groove (Fig