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Moreover, ox-LDL triggers the immune response, damaged endothelial cells are activated and express monocyte chemoattractant proteins (MCP)-1 and 8, intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), E-selectin, P-selectin and other inflammatory factors (68)

By blocking the vascular endothelial growth factor, bevacizumab damages the tumor vascular system that leads to the breakdown of metastatic tumor cells in the dermis

Browning intensity Figure 3A and B shows the absorbance at 420 nm (A420nm) and the CIEL*a*b* blueyellow component (b*) of the various samples as indicators of browning intensity