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This signature suggests increased activation of protein damage repair mechanisms catalyzed by enzymes like PCMT1, which responds to oxidant stress-induced dehydration and deamidation of aspartate and asparagine residues, respectively 49

Benzyl alcohol was selected to refrain from decomposition of the final amino acids during the acid hydrolysis of, e.g., methyl esters [99] since for a mixture of 96 and 97 hydrogenolysis cleanly liberates (2 S ,3 S ,4 S )- 4 (Scheme 25) [100]

Weeks 1-4: Foundation phase The first month establishes tolerance and begins the cellular changes that eventually produce visible results

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