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Nanoplastics causes heart aging/myocardial cell senescence through the Ca2+/mtDNA/cGAS-STING signaling cascade

In line with this, it was shown that cancer cells with KEAP1 mutation and/or NRF2 hyperactivation exhibit increased glutamine dependency and enhanced sensitivity to glutamine deprivation or glutaminase inhibition, partly via high SLC7A11-mediated glutamate export in these cancer cells (Romero et al., 2017

In the context of wound healing and surgery, especially for geriatric patients who may have limited muscle reserves, this alanine shuttle helps spare muscle from excessive ammonia accumulation by exporting nitrogen to the liver as alanine