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You should contact your GP if you experience: Persistent fatigue or weakness that affects daily activities Tingling, numbness, or pins and needles in your hands or feet Difficulty with balance or coordination Memory problems or difficulty concentrating Mood changes, particularly low mood or irritability A sore, red tongue or recurrent mouth ulcers Unexplained shortness of breath or palpitations These symptoms warrant investigation, which typically includes blood tests to measure B12 levels (or active B12 depending on the laboratory), full blood count to assess for anaemia, folate levels, and potentially other tests such as anti-intrinsic factor antibodies if pernicious anaemia is suspected

Still, when used in supplements, theyre produced in a lab rather than being isolated from natural sources

Pernicious anemia is an autoimmune disease where the body cant make enough healthy red blood cells, may also benefit from a B12 supplement, the NIH says

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