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Treatment involves an initial trial of NSAIDs, activity modification and physical therapy

References Abinandan, S., Subashchandrabose, S

Histologically, epidermal thickening, severe hyperkeratosis, and epidermal acanthosis were seen ( Mll4 -knockout mice developed red, scaly skin ( Alox12 , Alox12b , and AloxE3 expressions were downregulated

First, it is an endogenous molecule: it circulates in human plasma at a concentration of roughly 200 ng/mL around age 20, declining to about 80 ng/mL by age 60, a fall that has been linked, at least associatively, to the general decline in tissue regenerative capacity with age