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Danish, R., Lee, P., Mazur, T., Amrhein, J

The inhibition of monoamine oxidase by tricyclic antidepressants: the influence of the nature of the substrate and the source of the enzyme

This proteasomal inhibiting role can lead to a reduced proteasomal elimination of ubiquinated P-I (phosphorylated-inhibitor kappa), inhibiting nuclear translocation of NF-, suppressing NF-B activation and its consequences of tumor necrosis factor alpha (TNF-), and NO production (56) as well as, prophylactic atorvastatin suppresses NF-B activation in trigeminal nucleus caudalis (57)

220 Therefore, it is highly important to explore the relationships among lipid and glucose metabolism, mitochondria metabolic function and ferroptosis in metabolic diseases such as diabetes, hyperlipidemia, and obesity