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A series of mutants impaired in other genes putatively involved in glutathione homeostasis were however not more susceptible than WT

In contrast, an overdose of APAP causes hepatotoxicity by saturating the sulfation pathway and generating NAPQI that leads to a robust reaction between NAPQI and hepatic glutathione stores, which subsequently depletes glutathione (Xie et al., 2015)

NSC48160, a Kirsten rat sarcoma viral oncogene homolog (KRAS) inhibitor, indirectly suppresses the NRF2-SLC7A11-GPX4 axis by disrupting the tricarboxylic acid (TCA) cycle, thereby promoting ferroptosis in KRAS-mutant HCC models [47]

doi: 10.1016/s0891-5849(00)00281-1