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Preclinical studies in rodents with pilocarpine- and kainate-induced temporal lobe epilepsy showed high levels of ROS/RNS, lipid peroxidation with consequent hippocampal apoptosis, damage of membranes and organelles, protein synthesis in survived neurons and altered gene expression, and GSH action was reduced extensively (Atanasova et al., 2013, Pearson et al., 2015)

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