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Impact of a high-fat diet on tissue Acyl-CoA and histone acetylation levels

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From a pharmacokinetic perspective, poor metabolizers exhibit longer drug half-life and higher plasma concentrations, potentially enhancing antidepressant efficacy but concurrently increasing the risk of adverse effectsa dynamic balance that reinforces the clinical importance of genotype-guided dosing ( 8 Integrating pharmacogenetic evidence: CYP2D6 and CYP2C19 polymorphisms in antidepressant response and clinical translation Although Li et al

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