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While the sensation isnt a medical condition on its own, it may be a symptom of an underlying gastrointestinal condition

Ther Clin Risk Manag 4:913917 Delaney CP, Chang E, Senagore AJ, Broder M (2008) Clinical outcomes and resource utilization associated with laparoscopic and open colectomy using a large national database

Accumulating evidence indicates that alterations in gut microbiota composition can compromise its functional efficacy and disrupt intestinal barrier integrity, precipitating a state of low-grade chronic inflammation

Tolerability (early human safety): Short human studies reported a placebo-like safety profile with no serious adverse events [5] [6]