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As a severe X-linked neurodevelopmental disorder, RTT predominantly affects females, with the majority of cases resulting from MECP2 mutations both within and outside the methyl-CpG binding domain (MBD) (98)

It improves cardiovascular functions and athletic performance

Although clinicians and researchers have been successful in mitigating the progression of chronic diseases to a certain extent through surgery and drugs, the interventions are associated with high medical costs, reduced quality of life, and increased risk of complications (4)

ICIs have also introduced a new pattern of immune-related adverse events (irAEs)