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Biogerontology, R

Research indicates that SAMe also suppresses the transcription of the TNF- gene, by preventing the nuclear translocation of NF-B (Figures 14A,B), which may be attributable to improved antioxidant status and enhanced ROS neutralization, thereby potentially attenuating a key upstream driver of NF-B activation (Yu et al., 2020)

Moreover, as metabolic changes have also been observed in tissue samples acquired prior to the onset of postoperative AF, these changes may contribute to AF onset rather than arising only as a consequence of AF [81]

Kale A, Sankrityayan H, Anders HJ, Gaikwad AB (2021) Epigenetic and non-epigenetic regulation of Klotho in kidney disease