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[DOI] [PMC free article] [PubMed] [Google Scholar] 105.Yasmin T., Menon S.N., Pandey A., Siddiqua S., Kuddus S.A., Rahman M.M., Khan F., Hoque N., Rana M.S., Subhan N., et al

As the disease progresses, the decrease in cortisol and prolonged exposure to antigens may lead to relative immunodeficiency and depletion of the immune system, which is reflected in an increase in the expression of molecules such as PD-1 and CTLA4 (143)