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Reproductive sciences (Thousand Oaks

doi: 10.1158/1078-0432.CCR-06-2491 127 ErnstSMller-NewenG

at the same time, AP-1 downregulates the expression of transforming growth factor- (TGF-) receptor type II, which disrupts the downstream Smad/TGF- signal pathway, thereby reducing the transcription of the COL1A1 and COL3A1 genes encoding type I and type III collagen (41,50-52)