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Although methotrexate didnt improve heart health, it was associated with several troubling side effects compared to placebo, including: A 23% higher rate of gastrointestinal (GI) symptoms, such as nausea and vomiting A 42% higher rate of lung problems, including cough, trouble breathing and in a small percentage of people, pneumonitis, a potentially fatal lung inflammation A 15% increase in infections A doubled risk of skin cancer, although the overall rate was low Two kinds of side effects can occur in children who take methotrexate for JIA: symptoms, particularly nausea and vomiting, caused by the drug itself and by anticipating taking it

Dclaration des effets indsirables suspects La dclaration des effets indsirables suspects aprs autorisation du mdicament est importante

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