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Abstract Background Smoking tobacco is a leading cause of chronic obstructive pulmonary disease (COPD), but although the majority of COPD cases can be directly related to smoking, only a quarter of smokers actually develop the disease

In addition, patients with SJS/TEN have a mean loss of life expectancy of approximately 9 years [18]

But many people, for various reasons, dont have the luxury of getting out into the sunlight every single day

This indicates substantial phenotypic heterogeneity and suggests that metabolic factors likely act as potent disease accelerants in genetically or biomechanically susceptible individuals, rather than being universal initiators (34)