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5-Amino-1MQ, as an NNMT inhibitor, alters a pathway involved in NAD+ and methylation balance, and its long-term effects in people are simply unstudied

In addition to its expression in glial cells, GABA-T is also expressed in brain capillary endothelial cells, where it is believed to act as a neurotransmitter-metabolizing enzyme that possibly hydrolyzes circulating GABA and protects it from entering the brain 33

doi: 10.1038/nri3859 66 ChiangNSerhanCN

Also shown in Figure 7 and Tables 2 and 4, affinities and potencies of both metabolites at 5-HT 1A Rs were similar, though lower, than those of the parent compounds