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PMID: 4696188 [2] Paul C, Brady DM

doi:10.3389/fneur.2020.00997

MOTS-c administered before NAD+ preservation means AMPK activation occurs while NNMT is still methylating nicotinamide and depleting NAD+ pools

Because collagen is a protein-rich supplement and tied to amino acids involved in creatine metabolism, questions like Does collagen increase creatinine levels matter to anyone monitoring renal health.