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BioJiva reports results of pilot phase 2 clinical trial of RT001 in patients with amyotrophic lateral sclerosis (ALS)

Produced mainly by activated T cells and Th17 cells, IL-17 specifically targets the extracellular domain of the tight junction protein Claudin-5 in the BBB, disrupting inter-endothelial connections and serving as a crucial mechanism for BBB damage (111)

Biochimie (Paris) 2019;159:107-11

Spirochetes and mobile Gram-negative anaerobes are the bacteria most often linked to implant failure unless the cause is a straightforward mechanical overload [119]