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The online tool exoRBase 2.0 ( was used to identify ovarian cancer-associated protein levels in peripheral blood exosomes and to predict diagnostic markers [32]

Furthermore, during tumor proliferation, the UPS may influence various oncogenic signaling cascades, concurrently dysregulating multiple pathways and thereby complicating the development of targeted therapeutic strategies

If homocysteine concentrations are raised, dietary modification, optimisation of folate and B vitamin intake, and where appropriate, targeted supplementation can often reduce levels

In addition, the depletion of NMD factors, including Upf1, delays spontaneous differentiation to embryoid body (EB) formation, suggesting that NMD may be involved in the early stage of differentiation 15