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Clinical studies have shown that patients with the stromal subtype generally present with more advanced disease at diagnosis and have a poorer prognosis, whereas patients with the immunoreactive subtype may be diagnosed at earlier stages and tend to respond more favorably to standard treatments ( Furthermore, the tumor microenvironment (TME) of HGSOC displays distinct characteristics across various subtypes

The primary pathophysiological mechanism involves the rupture of small cerebral blood vessels or microaneurysms, often resulting from chronic hypertension, with sudden blood pressure spikes frequently acting as triggers [4]