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The inflammatory cellular infiltration, such as neutrophils and macrophages, mediating prolonged airway inflammation can be induced, and inflammatory cytokines are released, such as TNF- as an initial proinflammatory cytokine stimulating the expression of downstream cytokines, such as IL-1(6)

A few pilot phase 1/2 trials assessing the effect of NR supplementation (2000 mg/day) on systolic HF patients have been completed (e.g., NCT03423342, First Posted: 6 February 2018 and NCT03727646, First Posted: 1 November 2018 at but results regarding the HFs symptoms were not published yet at the time of this review