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Description

10.1016/j.hrthm.2019.10.001 3

In animals and humans, the following factors are associated with a reduced GSH status: Chronic inflammation Sustained ROS production depletes the GSH pool faster than synthesis can keep up

Bound T4 is attached to proteins that render it biologically inactive

To control that this basal activity is really mediated by MRP1, we mutated in MRP1 WT a cluster of 6 residues that were proven to be involved either in GSH binding or transport, R1138, R1142 38 , S1252, E1253 39 , or in binding of the GSH moiety of LTC 4 , R1249 and N1245 40