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*Correspondence: Martin Joyce-Brady, The Pulmonary Center, Boston University School of Medicine, 715 Albany Street, R304, Boston, MA 02118, USA e-mail: [email protected] This article was submitted to Experimental Pharmacology and Drug Discovery, a section of the journal Frontiers in Pharmacology

Funding We appreciate the funding support from National Institutes of Health (NIH) award RHL143545-01A1

Mild depression is another one of the most common side effects of B-vitamin depletion - blame that hungover grumpiness on your B vitamin levels

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