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Acyl-CoA thioesters possess an electrophilic carbonyl-carbon and are able to undergo non-enzyme catalyzed transacylation reactions with biological nucleophiles leading to covalent binding to protein and drug-protein adduct formation

The bone graft substitute was also implanted into beagles mandibular defects for 4 and 8 weeks, and the dogs were euthanized under excessive pentobarbital anesthesia and sampled for micro-CT scanning (Fig

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Metabolic diseases are becoming increasingly common in modern society, such as diabetes, NAFLD, and non-alcoholic steatohepatitis (NASH) due to people's lifestyles and irregular circadian rhythms [96]