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Microorganisms 10:802

[14] Should renal function be checked before each dose

The prevalence of B12 deficiency in those older than 60 years is between 10% and nearly 20%.7,8 Because multiple causes can coexist in elderly patients, including poor absorption, protracted metformin use, and reduced dietary intake, these patients have the greatest risk for B12 deficiency and should be carefully monitored for signs of deficiency

While generally safe, professional guidance is advised if you: Are pregnant or breastfeeding Have asthma or sulfur sensitivity Are undergoing chemotherapy Have chronic liver or kidney conditions Smart supplementation is about precision, not excess