glutathione levels in breast cancer cells

glutathione levels in breast cancer cells (GSH) Human Cell Lines Exposed for 24 h to Each Excessive glutathione intake contributes to

Name: glutathione levels in breast cancer cells (GSH) Human Cell Lines Exposed for 24 h to Each Excessive glutathione intake contributes to
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Excessive glutathione intake contributes to chemotherapy resistance in breast cancer: a propensity score matching analysis World Journal of Surgical Oncology Springer Nature Link Glutathione and Xanthine Metabolic Changes in Tamoxifen Resistant Breast Cancer Cell Lines are Mediated by Down Regulation of GSS and XDH and Correlated to Poor Prognosis Adipocyte derived glutathione promotes obesity related breast cancer by regulating the SCARB2 ARF1 mTORC1 complex: Cell Metabolism Glutathione peroxidase 4 inhibition induces ferroptosis and mTOR pathway suppression in thyroid cancer Scientific Reports

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Notably, canonical GPX4 inhibitors, such as RSL3 and ML162, also inhibit thioredoxin reductase 1 (TXNRD1) 121,122

Since GSH is the final product of the homocysteine metabolism in the transsulfuration pathway by transferring sulfur from homocysteine to cysteine, a deficiency in transsulfuration pathway leads to excessive homocysteine production (hyperhomocysteinemia) and reduced GSH synthesis (159, 160)