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AMPK is activated in an energy-deprived state when the intracellular ratio of AMP/ATP increases to support catabolic processes and energy production, whereas mTOR is activated in nutrient-rich conditions (amino acids, glucose) and supports anabolism and growth [56]

As expected, the engagement mode of Cagri with AMYRs is mainly conserved with that of rAmy and characterized by the formation of a bypass motif (residues S19 Cagri- P25 Cagri ) (Fig

For instance, hormone imbalance contributes to menopausal discomforts in women, while men suffer from muscle mass loss