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In chronic neuroinflammation, microglia-targeting lipid nanoparticles (MG-LNPs) with siRNA payload have shown the therapeutic delivery of their payloads, as evidenced by improvements in reducing inflammation even when administered through non-optimal routes

Morsy MA, Patel SS, Bakrania A, Kandeel M, Nair AB, Shah JN, Akrawi SH, El-Daly M (2022) Ameliorative effect of a neoteric regimen of catechin plus cetirizine on ovalbumin-induced allergic rhinitis in rats

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One is a selective ghrelin-receptor agonist (GHRP) with clean preclinical pharmacology but thin human data