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doi: 10.1021/acs.jafc.1c04933 [DOI] [PubMed] [Google Scholar] 231.Wang L, Doherty GA, Judd AS, et al

a NNMT inhibitor such as a cation of Formula I or IA, or otherwise disclosed herein chemical entities e.g., nicotinamide riboside, nicotinamide mononucleotide the invention encompasses a method of providing muscular therapy by contacting a cell expressing NNMT with a NNMT inhibitor (such as a cation of Formula I or IA, or otherwise disclosed herein) and one or more chemical entities (e.g., nicotinamide riboside, nicotinamide mononucleotide) that increases intracellular NAD+ levels to provide muscular therapy