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This finding highlights the vagus nerves integral role not only in neural regulation but also in conveying the effects of gut-derived metabolites, such as SCFAs, to the brain, thereby impacting synaptic plasticity and neuroinflammation

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Hyperglycemia affects endothelial nitric oxide synthase activity and nitric oxide production/bioavailability, nitric oxide-independent relaxing factors, oxidative stress, production and/or action of hormones, growth factors and/or cytokines, and generation and activity of opposing vasoconstrictors

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