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Three patients (11.5%) were able to stop DEX between 17-24 hours, while 6 patients (23.1%) could only discontinue DEX after 24 hours or more following clonidine administration

Quinolinic acid also modulates macrophage functioning, and drives immune tolerance through N-methyl-D-aspartate (NMDA) receptor and peroxisome proliferator-activated receptor gamma (PPAR) signaling (110)